Evaluation of serum triglyceride and cholesterol in subclinical Hypothyroidism

This study was aimed to evaluate the effects of subclinical hypothyroidism on lipid profile with special reference to total cholesterol and triglyceride levels. Analytic study. This study was carried out at the Punjab Institute of Nuclear Medicine [PINUM], Faisalabad and IMBB, university of Lahore from January 2011 to September 2011. [Eight months] 100 female patients of age ranges from 20-50 years having subclinical hypothyroidism [SCH] and 20 euthyroidsubject of same age and sex [control] were included in this study. Serum FT[4], FT[3], TSH, total cholesterol and triglyceride of subclinical hypothyroid patients and control group were determined. In subclinical hypothyroid patients total cholesterol were significantly increased as compared to euthyroid group. Serum TSH and total cholesterol showed positive correlation. Serum triglyceride did not significantly increased in SCH. The total cholesterol level elevated in SCH. This increases the risk of atherosclerotic coronary artery disease [CAD] in subclinical hypothyroid patients

Serum ferritin level in thalassemic patients of 10-15 years and its relationship with thyroid function tests

To determine the prevalence of hypothyroidism and to evaluate any possible correlation between serum ferritin level and thyroid function tests in transfusion dependent beta-thalassemic patients. An observational and correlation study. This study was conducted at DHQ hospital, Hilal-e-Ahmar hospital and Ali Zaib Foundation hospital Faisalabad from 15[th] of May 2011 to 15[th] of Jan 2012. A total number of 90 thalassemia major patients, of 10-15 years of age, were included in this study. Serum levels of thyroxine, tri-iodothyronine, thyroid stimulating hormone were determined and correlated with serum ferritin level. Five milliliters of blood was drawn from each subject and thyroid profile [T[3], T[4] and TSH] and serum ferritin were determined. Pearson correlation coefficient test was applied to determine any correlation between serum ferritin level and other parameters. There was a weak negative correlation of Serum Ferritin with both Triiodothyronine and Thyroxine, but both correlations were statistically insignificant [p-value= 0.294 and 0.189 respectively]. Serum Ferritin had a weak positive, but insignificant correlation with TSH. Hypothyroidism was detected in 15 patients [16.67%]. Out of these 8 [8.89%] were having subclinical hypothyroidism, 5 [5.56%] mild hypothyroidism, 1 [1.11%] overt hypothyroidism and 1[1.11%] patient having secondary hypothyroidism. High prevalence of hypothyroidism warrants regular screening of thyroid functions in thalassemic patients irrespective of their serum ferritin levels